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Nucleic Acids Symposium Series 2008 52(1):149-150; doi:10.1093/nass/nrn076
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© 2008 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: Joint Symposium of the 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry [View the issue table of contents]

A click chemistry approach towards nucleic acid major groove functionalization

Nicolai K. Andersen1, Lucie Spácilová1, Michael D. Jensen1, Petr Kocalka1, Frank Jensen2 and Poul Nielsen1,*

1Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, 5230 Odense M, Denmark; 2Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark.

*Corresponding Author. E-mail: pon{at}ifk.sdu.dk

Abstract

A synthetic strategy towards new aromatic nucleoside derivatives introducing additional aromatic functionality placed in the major groove of a modified DNA duplex is precented. The functionalities are introduced using Click Chemistry conditions and found to increase the overall duplex stability.


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