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Nucleic Acids Symposium Series 2008 52(1):167-168; doi:10.1093/nass/nrn085
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© 2008 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: Joint Symposium of the 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry [View the issue table of contents]

A short C-rich PNA fragment capable to form novel G-quadruplex-PNA complexes

Jussara Amato1, Valérie Gabelica2, Nicola Borbone1, Frédéric Rosu2, Edwin De Pauw2, Giorgia Oliviero1,*, Gennaro Piccialli1 and Luciano Mayol1

1Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli "Federico II", Via D. Montesano 49, I-80131 Napoli, Italy and 2Laboratoire de Spectrométrie de Masse, Université de Liège, Institut de Chimie Bat. B6c, B-4000 Liège, Belgium

*Corresponding Author. E-mail: golivier{at}unina.it

Abstract

In this work we investigated the interaction between the short ac4a C-rich peptide nucleic acid (PNA) probe and two intramolecular G-quadruplex targets having the same G-tetrad core, but different folding topologies. The T(G4T)3G4T and the recently reported tetra-end-linked-(TG4T)4 G-rich oligonucleotides (GROs) were chosen and synthesized for this study. UV, CD, and MS experiments revealed the formation of novel 1:1 G-quadruplex-PNA complexes besides the expected DNA-PNA heteroduplexes.


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