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Nucleic Acids Symposium Series 2008 52(1):21-22; doi:10.1093/nass/nrn011
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© 2008 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: Joint Symposium of the 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry [View the issue table of contents]

DNA Controlled Assembly of Liposomes

Ulla Jakobsen1, Adam C. Simonsen2 and Stefan Vogel1,*

1Nucleic acid Center 2Center for Biomembranes Physics, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark

*Corresponding Author. E-mail: snv{at}ifk.sdu.dk

Abstract

DNA-encoding of solid nanoparticles requires surfacechemistry, which is often tedious and not generally applicable. In the present study non-covalently attached DNA are used to assemble soft nanoparticles (liposomes) in solution. This process displays remarkably sharp thermal transitions from assembled to disassembled state for which reason this method allows easy and fast detection of polynucleotides (e.g. DNA or RNA), including single nucleotide polymorphisms as well as insertions and deletions.


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