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Nucleic Acids Symposium Series 2008 52(1):247-248; doi:10.1093/nass/nrn125
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© 2008 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: Joint Symposium of the 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry [View the issue table of contents]

Sensitive DNA probe for photochemical ligation prepared in click chemistry

Takehiro Ami2, Hiroshi Matsumura1 and Kenzo Fujimoto1,*

1School of Materials Science, Japan Advanced Institute of Science and Technology and 2Innovation Plaza Ishikawa, JST, 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan

*Corresponding author. E-mail: kenzo{at}jaist.ac.jp

Abstract

We report a new photosensitive probe, that takes advantage of the electronic structural changes associated with the triazole ring formed in the Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition. We succeeded in performing photoligation on the second time scale. Huisgen cycloaddition are employed to various labeling. As an example, we report a procedure for preparing the DNA probe for quick SNP typing.


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