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Nucleic Acids Symposium Series 2008 52(1):27-28; doi:10.1093/nass/nrn014
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© 2008 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: Joint Symposium of the 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry [View the issue table of contents]

Building Biologically Active Nucleic Acid Nanocomplexes

C. I. Edvard Smith1, Karin E. Lundin1, Oscar E. Simonson1, Pedro M.D. Moreno1, Mathias G. Svahn1, Malgorzata Wenska2 and Roger Strömberg2

1Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, Karolinska University Hospital, 141 86 Huddinge, Sweden, 2Department of Biosciences, Karolinska Institutet, Novum, 141 57 Huddinge, Sweden

Abstract

The Bioplex technology allows the hybridization of functional entities to various forms of nucleic acids by the use of synthetic nucleic acid analogs. Such supramolecular assemblies can be made in a predetermined fashion and can confer new properties. The Zorro technology is based on a novel construct generated to simultaneously bind to both DNA strands. Such compounds may have gene silencing activity.


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