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Nucleic Acids Symposium Series 2008 52(1):29-30; doi:10.1093/nass/nrn015
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© 2008 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: Joint Symposium of the 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry [View the issue table of contents]

Recognizing and Controlling Biomolecules with "Smart" Hybridization-based Switches

Oliver Seitz1,*, Tom N. Grossmann1, Stefanie Thurley1 and Lars Röglin2

1 Institute of Chemistry, Humboldt University Berlin, Brook-Taylor-Str. 2, D-12489 Berlin, Germany and 2 Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands

*Corresponding Author. E-mail: oliver.seitz{at}chemie.huberlin.de.

Abstract

The rules that govern the formation of DNA duplex structures are well known. On one hand, this process is used in the design of probe molecules that report the presence of target nucleic acids by responding to changes of structure and reactivity. On the other hand, molecules may be developed that transduce changes of nucleic acid structure to changes of peptide structure, and vice versa. Applications in the fields of bioanalytical chemistry and synthetic biology are discussed.


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