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Nucleic Acids Symposium Series 2008 52(1):31-32; doi:10.1093/nass/nrn016
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© 2008 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: Joint Symposium of the 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry [View the issue table of contents]

PNA-peptide conjugates as intracellular gene control agents

Gabriela D. Ivanova1, Martin M. Fabani1, Andrey A. Arzumanov1, Rachida Abes2, Haifang Yin3, Bernard Lebleu2, Matthew Wood3 and Michael J Gait1,*

1Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK, 2UMR 5235 CNRS, Université Montpellier 2, Place Eugene Bataillon, 34095 Montpellier, cedex 5, France and 3Department of Physiology, Anatomy and Genetics, University of Oxford, OX1 3QX, UK.

*Corresponding author. E-mail: mgait{at}mrc-lmb.cam.ac.uk

Abstract

Serum-stabilized PNA-internalization peptides (Pip) conjugated to PNA complementary to the 705 aberrant β-globin splice site are able to correct splicing and increase luciferase production in Hela pLuc705 cells with sub µM EC50 in the absence of a transfection agent. Inhibition of microRNA-122 in liver cells is achieved by treatment with complementary PNA containing just a few attached Lys residues, again without need of a transfection agent.


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