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Nucleic Acids Symposium Series 2008 52(1):47-48; doi:10.1093/nass/nrn024
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© 2008 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: Joint Symposium of the 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry [View the issue table of contents]

Click chemistry and Oligonucleotides: How a simple reaction can do so much

François Morvan1,*, Albert Meyer1, Gwladys Pourceau1, Sébastien Vidal2, Yann Chevolot3, Eliane Souteyrand3 and Jean-Jacques Vasseur1

1IBMM, UMR5247 CNRS Université Montpellier 1, Université Montpellier 2, Place E. Bataillon, CC1704, 34095 Montpellier Cedex 5, France, 2ICBMS, UMR 5246 CNRS Université Claude Bernard Lyon 1, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne, France, 3INL, UMR 5270, Ecole Centrale de Lyon, 36 avenue Guy de Collongue, 69134 Ecully cedex, France.

*Corresponding Author. E-mail: morvan{at}univ-montp2.fr

Abstract

Copper catalyzed Alkyne Azide 1,3-dipolar cycloaddition (CuAAC) "click reaction" was applied for the construction of oligonucleotide conjugates, circular objects and phosphodiester glyco-clusters. To this end, several strategies were developed to introduce either alkyne or azide functions into an oligonucleotide.


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