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Nucleic Acids Symposium Series 2008 52(1):5-6; doi:10.1093/nass/nrn003
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© 2008 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: Joint Symposium of the 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry [View the issue table of contents]

Nucleic acid duplexes with zippers of additional nucleobases and aromatics in minor or major groove

Poul Nielsen*, Khalil I. Shaikh, Lise J. Nielsen, Nicolai K. Andersen, Lucie Spácilová, Henrik Nielsen, Petr Kocalka and Mikkel S. Christensen

Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, 5230 Odense M, Denmark.

*Corresponding Author. E-mail: pon{at}ifk.sdu.dk

Abstract

Two series of thymidine derivatives with additional nucleobases/aromatics attached to either the 5'(S)-C- or the 5-position were prepared by epoxide opening and/or "click chemistry" cycloaddition protocols and introduced into DNA duplexes. Interstrand base-base communication in the minor groove and intrastrand stacking interactions in the major groove were detected.


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