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Nucleic Acids Symposium Series 2008 52(1):51-52; doi:10.1093/nass/nrn026
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© 2008 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: Joint Symposium of the 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry [View the issue table of contents]

A Whole Base-Labile Strategy for RNA Synthesis with 2'-O-acetalester Protections

Thomas Lavergne, Anthony Martin, Françoise Debart* and Jean-Jacques Vasseur

IBMM, UMR 5247 CNRS-UM1-UM2, CC 1704, Université Montpellier 2, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France

*Françoise Debart. E-mail: debart{at}univ-montp2.fr

Abstract

The use of base-labile groups for 2'-OH protection is a major challenge for RNA synthesis. A new method with acyloxymethyl groups has been developed. These groups were fully compatible with standard base-labile protections for nucleobases and phosphates and were removed in a short two-step all-base deprotection. Oligoribonucleotides were synthesized efficiently, rapidly and in high purity without chain rupture or isomerisation via this new whole base-labile strategy.


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