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Nucleic Acids Symposium Series 2008 52(1):61-62; doi:10.1093/nass/nrn031
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© 2008 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: Joint Symposium of the 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry [View the issue table of contents]

Physicochemical Stability of NOX-E36, a 40mer L-RNA (Spiegelmer) for Therapeutic Applications

Christian Maasch, Klaus Buchner, Dirk Eulberg, Stefan Vonhoff and Sven Klussmann*

NOXXON Pharma AG, Max-Dohrn-Strasse 8-10, D-10589 Berlin, Germany

*Corresponding Author. E-mail: sklussmann{at}noxxon.net.

Abstract

Spiegelmers are structured mirror-image oligonucleotides that are designed to bind and inhibit pharmacologically relevant target molecules. The synthesis and purification of mirror-image oligonucleotides is comparable to the manufacturing of standard oligonucleotides that consist of naturally configured nucleotides. Due to the use of the nonnatural L-nucleotides in Spiegelmers, these oligonucleotides show an exceptional biostability. Further, they also display a high physicochemical stability in solution. These properties make them interesting substances for drug development.


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