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Nucleic Acids Symposium Series 2008 52(1):619-620; doi:10.1093/nass/nrn313
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© 2008 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: Joint Symposium of the 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry [View the issue table of contents]

Base-Modified Ribonucleosides as Potential Anti-Hepatitis C virus Agents

A.V. Ivanov1,2, O.A. Smirnova1, N.A. Golubeva1, M.A. Ivanov1, V.L. Tunitskaya1, A.V. Shipitsyn1 and L.A. Alexandrova1,*

1Engelhardt Institute of Molecular Biology RAS, 119991 Moscow, Russia; 2University of Oslo, Centre for MedicalStudies in Russia, Moscow, Russia

*Corresponding Author. E-mail: ala2004_07{at}mail.ru

Abstract

Four novel series of base modified ribonucleoside analogues were synthesized and evaluated as potential anti-HCV agents. For two compounds notable anti-HCV activity was obserwed The triphosphates of bicyclic pyrimidine ribonucleosides were studied as substrates/inhibitors of HCV RNA-dependent RNA polymerase (RdRp, NS5B protein) and RNA helicase/NTPase (NS3 protein).


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