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Nucleic Acids Symposium Series 2008 52(1):7-8; doi:10.1093/nass/nrn004
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© 2008 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: Joint Symposium of the 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry [View the issue table of contents]

DNA and RNA Quadruplex ligands

Anne De Cian1, Julien Gros1, Aurore Guédin1, Meriem Haddi1, Sébastien Lyonnais1, Lionel Guittat1, Jean-François Riou1, Chantal Trentesaux1, Barbara Saccà1, Laurent Lacroix1, Patrizia Alberti1 and Jean-Louis Mergny1,*

1Muséum national d’Histoire naturelle USM 503, INSERM U565, CNRS UMR5153, Paris (France)

*Corresponding author. E-mail: mergny{at}mnhn.fr

Abstract

Guanine-rich nucleic acids can adopt unusual structures called guanine quadruplexes (G4) based on stacked guanine quartets. Both RNA and DNA backbones are compatible with G4 formation. As RNA and DNA quadruplexes may be recognized by ligands, it is important to understand the rules that govern the stability and specificity of these complexes. We explore the binding of a pyridine dicarboxamide derivative to various oligoribo- and oligodeoxyribo-nucleotides.


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