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Nucleic Acids Symposium Series 2009 53(1):11-12; doi:10.1093/nass/nrp006
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© 2009 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: The 6th International Symposium on Nucleic Acids Chemistry (36th Symposium on Nucleic Acids Chemistry) [View the issue table of contents]

Synthesis and properties of a novel 2',4'-BNA bearing a urea bridged structure

Aiko Yahara, Masaru Nishida, Takeshi Baba, Tetsuya Kodama, Takeshi Imanishi and Satoshi Obika*

Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan

*Corresponding author. E-mail: obika{at}phs.osaka-u.as.jp

Abstract

Three kinds of novel bridged nucleic acid (BNA) monomers bearing carbamate or urea bridged structures, were designed and synthesized. One of these monomers, a urea-type BNA monomer was successfully incorporated into oligodeoxynucleotides (ODNs), and properties of the ODNs were evaluated. The ODNs containing the urea-type BNA monomers showed RNA selective hybridizing profiles and significant enzymatic stability.


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