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Nucleic Acids Symposium Series 2009 53(1):13-14; doi:10.1093/nass/nrp007
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© 2009 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: The 6th International Symposium on Nucleic Acids Chemistry (36th Symposium on Nucleic Acids Chemistry) [View the issue table of contents]

Synthesis and properties of terminally modified oligonucleotides capable of short-RNA selective hybridization

Kohji Seio, Kazuya Miyazaki, Sayako Kurohagi, Yoshiaki Masaki, Hirosuke Tsunoda, Akihiro Ohkubo and Mitsuo Sekine

Department of Life Science, Graduate School of Bioscience and Technology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan

*Corresponding author. E-mail: kseio{at}bio.titech.ac.jp msekine{at}bio.titech.ac.jp

Abstract

We have developed 2'-O-methyl-RNAs having phosphorylated cyclohexane at the 5' and/or 3'-terminal adenine. These 2'-O-methyl-RNAs formed less stable duplex with the longer target RNA than that with the short target RNA. We tried to improve the short-RNA selective hybridization property by the synthesis of 2'-O-methyl-RNAs having terminal guanine modifications.


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