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Nucleic Acids Symposium Series 2009 53(1):15; doi:10.1093/nass/nrp008
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© 2009 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: The 6th International Symposium on Nucleic Acids Chemistry (36th Symposium on Nucleic Acids Chemistry) [View the issue table of contents]

Biochemical dissection of RISC assembly and function

Yukihide Tomari1,2,3

1Institute of Molecular and Cellular Biosciences, 2Department of Medical Genome Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Bunkyo-ku, Tokyo 113-0032, and 3PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan

*Corresponding author. E-mail: tomari{at}iam.u-tokyo.ac.jp

Abstract

Small silencing RNAs, including small interfering RNAs (siRNAs) and microRNAs (miRNAs), regulate expression of their target genes via RNA-induced silencing complex (RISC). RISC assembly follows complex, ordered pathways, and RISC function is as diverse as cleavage, translational repression, and deadenylation of the target. We have recently shown how siRNAs and miRNAs are assembled into distinct types of RISC, and how differently they function, using Drosophila as a model organism.


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