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Nucleic Acids Symposium Series 2009 53(1):25; doi:10.1093/nass/nrp013
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© 2009 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: The 6th International Symposium on Nucleic Acids Chemistry (36th Symposium on Nucleic Acids Chemistry) [View the issue table of contents]

Role of microRNAs in the pathogenesis of human cance

Carlo M. Croce

College of Medicine Molecular Virology, Immunology & Medical Genetics – Human Cancer Genetics, The Ohio State University, 385L Wiseman Hall, 410 W TWELFTH AVE., COLOMBUS, OH 43210, USA

*Corresponding author. E-mail: Carlo.croce{at}osumc.edu

Abstract

Over the past few years, molecular oncology research has revealed that abnormalities in both protein coding genes (PCGs) and noncoding RNAs (ncRNAs) can be identified in tumors and that the interplay between PCGs and ncRNAs is causally involved in the initiation, progression and metastases of human cancers. MicroRNAs (miRNAs), which are among the most studied ncRNAs, are small 19- to 25-nucleotide genes involved in the regulation of PCGs and other ncRNAs. With the recent findings of miRNAs' involvement in cancer, miRNAs are strongly associated with the pathogenesis in human cancers. In this review, we focus on the possible mechanisms of miRNAs in cancer pathogenesis.


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