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Nucleic Acids Symposium Series 2009 53(1):27-28; doi:10.1093/nass/nrp014
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© 2009 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: The 6th International Symposium on Nucleic Acids Chemistry (36th Symposium on Nucleic Acids Chemistry) [View the issue table of contents]

Synthesis and properties of oligodeoxynucleotides containing biaryl units

Yoshihito Ueno1,2,3,5,*, Shinji Komatsuzaki1, Keiji Takasu1, Yoshiaki Kitamura1 and Yukio Kitade1,2,3,4

1Department of Biomolecular Science, Faculty of Engineering, Gifu University, 2United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 3Center for Emerging Infectious Diseases, Gifu University, 4Center for Advanced Drug Research, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan and 5PRESTO, Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan

*Corresponding author. E-mail: uenoy{at}gifu-u.ac.jp

Abstract

We describe the synthesis and properties of oligonucleotides (ONs) containing biaryl units, which are composed of a bis(hydroxymethyl)benzene residue and a naphthalene or pyrene moiety. We found that by introducing the biaryl units into the ONs, the aromatic chromophores are suitably arrayed in the DNAs. Further, we succeeded in the detection of a single-base mismatch in RNA by using the ON containing the biaryl unit as a molecular beacon.


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