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Nucleic Acids Symposium Series 2009 53(1):3-4; doi:10.1093/nass/nrp002
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© 2009 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: The 6th International Symposium on Nucleic Acids Chemistry (36th Symposium on Nucleic Acids Chemistry) [View the issue table of contents]

Alternative I-D exchange reaction on pyrimidine and purine nuclei mediated by tributyltin hydride using THF-d8 as a deuterium source

Tomonobu Mutsumi1,2, Kazuo Maruhashi1,3, Yasunari Monguchi2 and Hironao Sajiki2

1Chemical Technology Laboratory, Taiho Pharmaceutical Co., Ltd., 200-22 Motohara, Kamikawa-machi, Kodama-gun, Saitama 367-0241, Japan, 2Laboratory of Organic Chemistry, Department of Organic and Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan and 3Current address: Production Technology Section, Ace Japan Co., Ltd., 5850-1, Higashine-koh, Higashine, Yamagata 993-3701, Japan

*Corresponding author. E-mail: t-mutsumi{at}taiho.co.jp

Abstract

A novel method for the regioselective deuteration of pyrimidine and purine rings mediated by Bu3SnH using THF-d8 as a deuterium source on the basis of a radical reaction was developed.


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