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Nucleic Acids Symposium Series 2009 53(1):31-32; doi:10.1093/nass/nrp016
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© 2009 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: The 6th International Symposium on Nucleic Acids Chemistry (36th Symposium on Nucleic Acids Chemistry) [View the issue table of contents]

Investigation of the mechanism of the fluorescent emission of the silylated pyrene modified DNA

Tomohisa Moriguchi, Masayoshi Hattori, Tohru Sekiguchi and Kazuo Shinozuka*

Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma, 376-8515, Japan

*Corresponding author. E-mail: sinozuka{at}chem-bio.gunma-u.ac.jp

Abstract

Modified DNA containing silylated pyrene derivative at the 5'-terminus showed the obvious discrimination ability of the duplex formation, that the modified DNA showed the strong fluorescence emission in the presence of the complementary DNA, in spite of the very weak emission in the absence of the complementary DNA. The intensity of the fluorescence emission of the double strand found to increase about 10 times compared with that of the single strand. In this paper, we tried to disclose the detailed mechanism of such a discrimination ability of the silylated pyrene-modified DNA.


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