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Nucleic Acids Symposium Series 2009 53(1):33-34; doi:10.1093/nass/nrp017
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© 2009 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: The 6th International Symposium on Nucleic Acids Chemistry (36th Symposium on Nucleic Acids Chemistry) [View the issue table of contents]

Toward a reciprocal evolution system between RNA and peptides as an artificial model for the early RNP world

Yoshiya Ikawa*,1,2, Hiroyuki Furuta1, Kohei Yamashita1 and Norimasa Kashiwagi1

1Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan and 2PRESTO, Japan Science and Technology Agency (JST), 5 Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan

*Corresponding author. E-mail: yikawa{at}cstf.kyushu-u.ac.jp

Abstract

In the early stages of the evolution of life, RNA–polypeptide complexes (RNPs) have been suggested to play crucial roles. At a certain developmental stage of ancient RNPs, their RNA and polypeptide components could evolve in an interdependent manner to develop complex structures and functions. To mimic this possible process, we have designed an RNA molecule that can act as a template for chemical peptide ligation. This designed RNA possesses two peptide-binding sites that capture the two basic peptides. The designed RNA actually facilitated the peptide ligation. The resulting ligated peptide, which has two RNA binding sites, can in turn function as a trans-activator that enhances the intrinsic ribozymatic activity of the designed RNA.


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