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Nucleic Acids Symposium Series 2009 53(1):43; doi:10.1093/nass/nrp022
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© 2009 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: The 6th International Symposium on Nucleic Acids Chemistry (36th Symposium on Nucleic Acids Chemistry) [View the issue table of contents]

Chemical methods to study protein-nucleic acid interactions

Chuan He*

Department of Chemistry, The University of Chicago, 929 East 57th Street, Chicago, Illinois, 60637, USA

*Corresponding author. E-mail: chuanhe{at}uchicago.edu

Abstract

Accumulation of genetic changes due to the presence of unrepaired DNA lesions can lead to cancer development and other diseases. Nucleic acid modifications also play key roles in many essential life processes. We have developed a series of chemically modified nucleic acid analogues that can be applied to stabilize protein-nucleic acid interactions for structural and proteomic studies. Some of the probes have also been employed to study nucleic acid-nucleic acid interactions.


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