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Nucleic Acids Symposium Series 2009 53(1):5-6; doi:10.1093/nass/nrp003
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© 2009 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: The 6th International Symposium on Nucleic Acids Chemistry (36th Symposium on Nucleic Acids Chemistry) [View the issue table of contents]

Rational design and synthesis of ansa-adenosines as potential antitumor agents

Kazuhiro Muranaka, Satoshi Ichikawa* and Akira Matsuda*

Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan

*Corresponding authors. E-mail: ichikawa{at}pharm.hokudai.ac.jp matuda{at}pharm.hokudai.ac.jp

Abstract

Synthesis of benzoquinone ansa-adenosines, which are rationally designed as Hsp90 inhibitors by extracting and fusing a natural substrate, ATP, and a natural product, geldanamycin, was described. This simpler scaffold design provides practical synthesis of a set of analogs and demonstrates synthetic innovation.


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