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Nucleic Acids Symposium Series 2009 53(1):61-62; doi:10.1093/nass/nrp031
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© 2009 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: The 6th International Symposium on Nucleic Acids Chemistry (36th Symposium on Nucleic Acids Chemistry) [View the issue table of contents]

Cationic comb-type copolymer as a nucleic acid chaperone for DNA quadruplex

Rui Moriyama1, Naohiko Shimada1, Arihiro Kano1 and Atsushi Maruyama1,2,*

1Insititute of Materials Chemistry and Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan and 2CREST, Japan Science and Thecnology Agency (JST), 4-18 Honcho, Kawaguchi, Saitama 332-0012, Japan.

*Corresponding author. E-mail: Maruyama{at}ms.ifoc.kyushu-u.ac.jp

Abstract

The intermolecular DNA quadruplex is attractive materials for design of nanomolecular constructs and machines. This folding kinetics is, however, slow, hampering its application to these materials. We have reported that the cationic comb-type copolymer accelerated duplex and triplex formation. In this study, the effect of the copolymer on the intermolecular quadruplex folding was investigated. The copolymer was found to accelerate the association of intermolecular quadruplex by three-orders. Furthermore, the copolymer induced the strand exchange reaction between intermolecular quadruplex and its single-stranded counterparts. We suggested that the copolymer acts as a nucleic acid chaperone for the intermolecular quadruplex.


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