Skip Navigation

Nucleic Acids Symposium Series 2009 53(1):9-10; doi:10.1093/nass/nrp005
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Iwamoto, N.
Right arrow Articles by Wada, T.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Iwamoto, N.
Right arrow Articles by Wada, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2009 Oxford University Press

This article appears in the following Nucleic Acid Symposium Series issue: The 6th International Symposium on Nucleic Acids Chemistry (36th Symposium on Nucleic Acids Chemistry) [View the issue table of contents]

Stereocontrolled synthesis of oligodeoxyribonucleoside boranophosphates via stereodefined H-phosphonate intermediates

Naoki Iwamoto1,2, Natsuhisa Oka1,3 and Takeshi Wada1,*

1Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Bioscience Building 702, Kashiwanoha 5-1-5, Kashiwa, Chiba 277-8562, Japan, 2Chiralgen, Ltd, Tokatsu Techno Plaza 601, Kashiwanoha, Kashiwa, Chiba 277-0882, Japan and 3Department of Chemistry, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan

*Corresponding author. E-mail: wada{at}k.u-tokyo.ac.jp

Abstract

P-Stereodefined oligodeoxyribonucleoside boranophosphates (PB-ODNs) were succecfully synthesized by the conversion of diastereopure H-phosphonate intermediates. Thermal denaturation studies clearly showed that the duplex stability of PB-ODNs with the complementary DNA and RNA depends on the stereochemistry of the boranophosphate linkages.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.