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Nucleic Acids Symposium Series 2001 1(1):19-20; doi:10.1093/nass/1.1.19
© 2001 by Oxford University Press
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Structure and properties of carbocyclic 5'-Nor oligodeoxynucleotides

Masakazu Koga1, Koichi Tamai1, Mitsunori Ueda1, Toshinori Uchida1, Toshiyuki Yamamuro1, Takaaki Suzuki2 and Toshiaki Saeki3

1 Department of Applied Chemistry, Faculty of Engineering, and Venture Business Laboratory, Ehime University, Matsuyama 790-8577, Japan, 2 Industrial Research Center of Ehime Prefecture, Matsuyama 791-1101, Japan, 3 National Cancer Center Hospital East, Chiba 277-8577, Japan

The hybridization properties of carbocyclic 5'-nor oligodeoxynucleotides 1, 2 (24 mer, B= A) with DNA and RNA were investigated by CD melting curves. These oligomers formed unstable duplexes with DNA, but formed stable duplexes with RNA selectively.


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