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Nucleic Acids Symposium Series 2001 1(1):47-48; doi:10.1093/nass/1.1.47
© 2001 by Oxford University Press
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Adduct formation between oxanine and amine derivatives

Toshiaki Nakano1, Hiroaki Terato1, Kenjiro Asagoshi1, Yoshihiko Ohyama1, Toshinori Suzuki2, Masaki Yamada2, Keisuke Makino2 and Hiroshi Ide1

1 Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima 739-8526, Japan, 2 Institute of Advanced Energy, Kyoto University, Gokasho, Uji 611-0011, Japan

Oxanine (Oxa) is a major guanine lesion produced by nitric oxide (NO) under aerobic conditions. To elucidate the genotoxic mechanism of Oxa, this lesion was site-specifically incorporated into an oligonucleotide and allowed to react with cellular amines. Analysis of the reaction product revealed that Oxa formed adducts with spermidine and lysine, suggesting a novel genotoxic mechanism associated with NO-induced DNA damage.


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