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Nucleic Acids Symposium Series 2001 1(1):69-70; doi:10.1093/nass/1.1.69
© 2001 by Oxford University Press
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Synthesis of small multifunctional molecules having nucleic acid binding property

Kumiko Nakanuma, Tomohisa Moriguchi, Hideo Suzuki and Kazuo Shinozuka

Department of Chemistry, Faculty of Engineering, Gunma University, Tenjin-cho, Kiryu, Gunma 376-8515, Japan

We have previously reported that a multifunctional conjugate having the acridine derivative as an intercalative molecule and the polyamine moiety as an RNA cleaving molecule bound to a double helical RNA and cleaved the target efficiently. Along the study to develop a sequence and site specific artificial RNA cleaving molecule, we have development a novel intercalative molecule having polyamine moiety and DNA connecting function. The trisamine-acridine-tethered DNA is expected to bind to the complementary RNA and cleave the phosphodiester bond of the RNA near the position of the built-in interecalator.


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