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Nucleic Acids Symposium Series 2002 2(1):59-60; doi:10.1093/nass/2.1.59
© 2002 by Oxford University Press
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Investigation of DNA strand exchange mechanisms mediated by cationic polymers

Yuichi Sato2, Won Jong Kim1, Sung Won Choi1, Minako Saito2, Arihiro Kano2, Toshihiro Akaike1 and Atsushi Maruyama1,2

1 Department of Biomolecular Engineering, Tokyo Institute of Technology, 4259 Nagatsuta, Midori, Yokohama 226-8501, Japan, 2 Precursory Research for Embryonic Science and Technology, Japan Science and Technology Corporation, 4-1-8 Honcho, Kawaguti, Saitama 332-0012, Japan

It was observed that conjugation of dextran for PLL provided PLL-g-Dex with new properties of enhancing and accelerating inter-nucleotide recognition (1, 2, 3). In this paper, we report the effects of cationic PLL-g-Dex copolymers on base-pair formation of self-complementary octamer oligonucleotide by using NMR and CD analysis. NMR studies revealed that PLL-g-Dex copolymer did not affect hydrogen-bondings between bases in DNA duplex. CD studies also supported inert nature of the copolymer upon hybrid structure.


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