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Nucleic Acids Symposium Series 2002 2(1):63-64; doi:10.1093/nass/2.1.63
© 2002 by Oxford University Press
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Effect of secondary structure of short double-stranded RNA on RNAi efficiency

Tatsuo Ohmichi1,2, Hisae Karimata3 and Naoki Sugimoto1,3

1 High Technology Research Center, The University of Tokyo, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan, 3 Department of Chemistry, Faculty of Science and Engineering, = 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan, 2 I.S.T Corporation, 13-13-5 Ichiriyama, Otsu, Shiga 520-2153, Japan

The dangling nucleotides are very important for the RNA interference (RNAi). We investigate the effect of the dangling end on both the thermodynamic property of the RNA helix and efficiency of gene regulation in RNAi pathway. The result indicates that the four dangling adenines, which are more stable than two or three dangling residues, is not suitable for the RNAi efficiency.


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