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Nucleic Acids Symposium Series 2003 3(1):15-16; doi:10.1093/nass/3.1.15
© 2003 by Oxford University Press
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Synthesis of apio analogues of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase

Jeong A. Lee, Byul Nae Yoo, Won Jun Choi, Hyung Ryong Moon and Lak Shin Jeong

Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea

Stereoselective synthesis of apio-neplanocin A and its related purine nucleosides which combined the properties of neplanocin A and apio nucleoside was achieved, starting from D-ribose via regioselective hydroxymethylation and ring-closing metathesis (RCM) as key steps. However, all synthesized compounds did not show significant inhibitory activity against S-adenosylhomocysteine hydrolase, unlike neplanocin A


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