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Nucleic Acids Symposium Series 2003 3(1):25-26; doi:10.1093/nass/3.1.25
© 2003 by Oxford University Press
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Synthesis and hypnotic-sedative activities of N-substituted uracil on mice

Tokumi Maruyama1,2, Shigetada Kozai2, Tomomi Shimizu3, Toshiyuki Kimura3, Kazuhito Watanabe3 and lkuo Yamamoto1

1 School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka 882-8508, Japan, 2 Faculty of Pharmaceutical Sciences, Tokushima Bunri University Yamashiro-cho 180, Tokushima 770-8514, Japan, 3 Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa 920-1 181, Japan

N3-Phenacyl-N1-substituted uracils 3a-q were synthesized by introduction of substituents at the N1-position of 9-phenacyluracil 2, and their hypnotic and sedative activities were evaluated. Pharmacological activities of these N3-phenacyl-N1-substituted uracils were examined using hypnotic activity and synergistic effects with pentobarbital or diazepam for the hypnotic and sedative activities.


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