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Nucleic Acids Symposium Series 2003 3(1):63-64; doi:10.1093/nass/3.1.63
© 2003 by Oxford University Press
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Synthesis of double-headed 2-5A-antisense chimeras and their ability to activate human RNase L

Yoshihito Ueno, Shusaku Okatani, Yuuki Yamada and Yukio Kitade

Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido, Gifu 501-1193, Japan

The synthesis of a novel 2-5A-antisense chimera having two molecules of 2-5A tetramer at the 5'-terminus of the antisense moiety with an ethylene glycol linker is described. The ability of the synthesized 2-5A antisense chimeras to activate RNase L was estimated by monitoring the cleavage of a target RNA by the activated RNase L. It was found that the double-headed 2-5A-antisense chimera linked with two molecules of a butanediol linker more efficiently cleaved the target RNA as compared with the single-headed 2-5A-antisense chimera and the double-headed 2-5A-antisense chimera linked with a molecule of the butanediol linker.


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