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Nucleic Acids Symposium Series 2003 3(1):69-70; doi:10.1093/nass/3.1.69
© 2003 by Oxford University Press
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Photochemistry of bromouracil containing Z-DNA

Ryu Tashiro1 and Hiroshi Sugiyama1,2

1 Division of Biofunctional Molecule, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062 Japan, 2 Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan

To investigate the mechanism underlying the photoreaction of bromouracil in DNA, a detailed analysis of photoirradiated 5'-d(CGCGBrUGCG)-3'/5'-d(C8MeOGCACmGCG)-3' was undertaken. We found that rG- and 2-aminoimidazolone-containing octanucleotides are formed efficiently in Z-form DNA. These results suggest that interstrand electron transfer initiates the photoreaction of bromouracil in Z-DNA.


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