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Nucleic Acids Symposium Series 2003 3(1):75-76; doi:10.1093/nass/3.1.75
© 2003 by Oxford University Press
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Photodynamic antisense therapy: regulation of cervical carcinoma cells by psoralen-conjugated oligonucleotides

Asako Yamayoshi1, Kiyoko Kato2, Reiko Iwase3, Tetsuji Yamaoka1, Norio Wake2 and Akira Murakami1

1 Department of Polymer Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Kyoto 606-8585, Japan, 2 Department of Reproduction Physiology and Endocrinology, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumihara, Oita 874-0838, Japan, 3 Department of Biosciences, Teikyo University of Science Technology, Uenohara, Kitatsuru, Yamanashi 409-0193, Japan

To reinforce antisense effects, we focused on the photo-cross-linking ability of psoralen derivatives and examined the applicability of the photodynamic antisense therapy to cancer cells using psoralen-conjugated oligo(nucleosides phosphorothioate)s (Ps-S-Oligo). The regulatory effects of Ps-S-Oligos on the proliferation of cervical carcinoma were evaluated. The inhibitory effects were found to be significant (IC50=16nM) without any drug delivery systems, and it was also found that the mechanism was associated with the p53 induced apoptosis. This result suggests that the photodynamic antisense therapy will be a the promising concept for the cancer therapy.


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