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Nucleic Acids Symposium Series 1999 42(1):151-152; doi:10.1093/nass/42.1.151
© 1999 by Oxford University Press
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Ultra-high resolution DNA structures

Andrew H.-J. Wang, Howard Robinson and Yi-Gui Gao

Department of Cell and Structural Biology, University of Illinois, at Urbana-Champaign, Urbana, IL 61801, USA

This paper describes the progress in our efforts at producing ultra-high resolution (< 0.8 Å) DNA structures using advanced cryo-crystallography and synchrotron. Our work is aimed at providing reliable geometric (bond length and bond angle), electronic and motional information of DNA molecules in different conformational contexts. These highly-reliable, new structures will be the basis for constructing better DNA force-field parameters, which will benefit the structural refinement of DNA, protein-DNA complexes, and ligand-DNA complexes.


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