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Nucleic Acids Symposium Series 1999 42(1):155-156; doi:10.1093/nass/42.1.155
© 1999 by Oxford University Press
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Formation of 8-nitroguanine from 2'-deoxyguanosine by NO/O2 system

Toshinori Suzuki1, Masaki Yamada1, Kenji Kanaori2, Kunihiko Tajima2, Takashi Morii1 and Keisuke Makino1

1 Institute of Advanced Energy, Kyoto University, Gokasho, Uji 611-0011, Japan, 2 Department of Polymer Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan

We investigated the reaction of 2'-deoxyguanosine (dGuo) with NO/O2 gas mixture under physiological condition and detected 8-nitroguanine, which is known as a novel DNA lesion caused by peroxynitrite (ONOO–). The yield increased with increase in the ratio of O2 and pH. The reaction mechanism is discussed.


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