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Nucleic Acids Symposium Series 1999 42(1):7-8; doi:10.1093/nass/42.1.7
© 1999 by Oxford University Press
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Reactivity of 2'-deoxyoxanosine, a novel DNA lesion

Toshinori Suzuki, Masaki Yamada, Takahiro Ishida, Takashi Morii and Keisuke Makino

Institute of Advanced Energy, Kyoto University, Gokasho, Uji 611-0011, Japan

2'-Deoxyoxanosine (dOxo) is a novel DNA lesion produced from 2'-deoxyguanosine by the reaction with nitrous acid or nitric oxide. We found that dOxo reacted with glycine under physiological conditions. The product was identified by spectrometric data as an adduct between the six membered ring of dOxo and an amino group of glycine. The adduct was more stable than dOxo under physiological conditions. The incubation of an oligodeoxynucleotide containing dOxo with glycine gave also rise to the adduct. These results suggest that dOxo formed in DNA reacts with amino groups of various compounds around DNA in vivo resulting in the adduct.


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S. P. Pack, M. Nonogawa, T. Kodaki, and K. Makino
Chemical synthesis and thermodynamic characterization of oxanine-containing oligodeoxynucleotides
Nucleic Acids Res., October 11, 2005; 33(18): 5771 - 5780.
[Abstract] [Full Text] [PDF]


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