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Nucleic Acids Symposium Series 2000 44(1):263-264; doi:10.1093/nass/44.1.263
© 2000 by Oxford University Press
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The structure and function of tRNA-like domain in E. coli tmRNA

Kyoko Hanawa1,2, SungGa Lee1, Hyouta Himeno1,2 and Akira Muto1,2

1 Department of Biochemistry and Biotechnology, Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki, Aomori 036-8561, Japan, 2 The United Graduate School of Agricultural Science, Iwate University, Iwate 020-8550, Japan

tmRNA has a dual function both as a tRNA and as an mRNA in trans-translation. tmRNA possesses structural elements similar to canonical tRNAs. Our mutation studies show that the tRNA-like structure is crucial for function as an mRNA as well as a tRNA.


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