Skip Navigation

Nucleic Acids Symposium Series 2000 44(1):75-76; doi:10.1093/nass/44.1.75
© 2000 by Oxford University Press
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Kumar, S.
Right arrow Articles by Misra, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kumar, S.
Right arrow Articles by Misra, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Design and synthesis of curcumin-bioconjugates to improve systemic delivery

Sanjay Kumar1, Krishna K Dubey2, Snehlata Tripathi1, Masayuki Fujii2 and Krishna Misra1

1 Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad-211 002, India, 2 Bioorganic Chemistry Laboratory, Department of Biological and Environmental Chemistry, Kyushu School of Engineering, Kinki University, 11-6 Kayanomori, lizuka, Fukuoka 820-8555, Japan

Di-O-glycinoyl curcumin (I), di-O-grydnoyl-C4-gtycyl-curcumin (II), 5'-deoxy-5'-curcuminyl thymidine (5'-cur-T) (III) and 2'-deoxy-2'-curcuminyl undine (2'-cur-U) (IV) have been synthesized and characetrised by elemental analysis & 1H NMR. The antibacterial activities of these four bioconjugates has been tested particularly for multiresistant micro-organisms. Best results are shown by I & IV. These bioconjugates serve dual purpose of systemic delivery as well as therapeutic agents against viral diseases.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.