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Nucleic Acids Symposium Series 2000 44(1):77-78; doi:10.1093/nass/44.1.77
© 2000 by Oxford University Press
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Quantification analysis of translation initiation signal in vertebrate mRNAs: Effect of nucleotides at positions +4 ~ +6 upon efficiency of translation initiation

Yôichi Iida and Daisuke Kanagu

Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan

Concerning initiation the translation signal in vertebrate mRNAs, a consensus sequence, (GCC)GCC(A or G)CCATGG, has been but actual initiation differ from it in a greater or lesser degree. Kozak monitored selection by ribosomes of the first versus second ATG codons as a function of mutations introduced at positions +4, +5, and +6 of the first ATG codon. Codons possessing G at +4 strongly enhanced selection of the first ATG codon. However, ATG codon recognition was unaffected by most mutations in positions +5 and +6. These data were well understood by our quantification analysis.


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