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Nucleic Acids Symposium Series 2000 44(1):79-80; doi:10.1093/nass/44.1.79
© 2000 by Oxford University Press
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Development of a novel functional biosensor with a short Ca2+-dependent deoxyribozyme

Yasuhide Okumoto1 and Naoki Sugimoto1,2

1 Department of Chemistry, Faculty of Science, Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan, 2 High Technology Research Center, Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan

We develop a novel functional biosensor on a deoxyribozyme. A 5'-end-immobilized short Ca2+-dependent deoxyribozyme (dCGCTGGCAGGCTACAACGAGTCTTC) binds to a target RNA substrate (rGAAGACA{downarrow}UGCCAGCG; {downarrow} denotes an RNA cleavage site), and acts as an enzyme in the presence of Ca2+. It cleaves the target RNA substrate at one site of rAp{downarrow}U in the asymmetric internal loop.


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