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Nucleic Acids Symposium Series 2004 48(1):171-172; doi:10.1093/nass/48.1.171
© 2004 by Oxford University Press
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Translesion synthesis by human DNA polymerase {eta} across oxidative products of guanine

Katuhito Kino1,2, Nobutoshi lto1, Kaoru Sugasawa1,3, Hiroshi Sugiyama4,5 and Fumio Hanaoka1,3,6

1 Cellular Physiology Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan, 2 Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa 799-2193, Japan, 3 CREST, Japan Science and Technology Agency, Japan, 4 Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan, 5 SORST, Japan Science and Technology Agency, Japan, 6 Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565-0871, Japan

Guanine is the most oxidizable base among natural bases. 8-Oxoguanine (8-oxoG) is the typical oxidative product, but the amount of 8-oxoG does not directly reflect the strength of oxidative stress. Imidazolone, oxazolone and guanidinohydantoin are oxidative products of guanine and 8-oxoG. Here, we investigated enzymatic reactions with human DNA polymerase {eta} on these lesions.


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