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Nucleic Acids Symposium Series 2004 48(1):209-210; doi:10.1093/nass/48.1.209
© 2004 by Oxford University Press
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A ligase ribozyme obtained from a structured pool

Wataru Yoshioka1, Yoshiya Ikawa2, Luc Jaeger3 and Tan Inoue2

1 Department of Chemistry, Graduate School of Science, Kyoto University, Japan, 2 Graduate School of Biostudies, Kyoto University, Japan, 3 Department of Chemistry and Biochemistry, UCSB, USA

Here we report the in vitro selection experiment employed to construct a catalytic site on a self-folding RNA. To practice the selection, the sequence of 30 nucleotides was located in close proximity of the putative reaction site in a derivative of a naturally occurring RNA with a well known 3D structure. The acquired catalytic RNA retained the starting 3D structure and was successfully reconstructed according to its modular structure.


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