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Nucleic Acids Symposium Series 2004 48(1):249-250; doi:10.1093/nass/48.1.249
© 2004 by Oxford University Press
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Chemical synthesis of oxanine-contained oligodeoxynucleotides

Seung Pil Pack1,2, Daihei Yamamoto2, Tsutomu Kodaki2 and Keisuke Makino1,2

1 International Innovation Center, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto 606-8501, Japan, 2 Institute of Advanced Energy, Kyoto University, Gokasyo, Uji, Kyoto 611-0011, Japan

Oxanine, one of major damaged produet from deamination of guanine base mediated by NO or HNO2-induced nilrosative reaction, has been considered as a genotoxic lesion. To analyze the biophysical properties of oxanine in context of oligodeoxynucleotide, the chemical incorporation of 2'-deoxyuxanosine (dOxo, nuclcoside form of oxanine) into oligodeoxynucleotide is required. Here, we developed the chemical synthesis procedures of dimethoxytritylaled dOxo-phosphoramidite (DMT-dOxo-amidite) and oxanine-contained oligonucleotide.


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