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Nucleic Acids Symposium Series 2004 48(1):25-26; doi:10.1093/nass/48.1.25
© 2004 by Oxford University Press
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Internucleotide-linkage formation via the phosphoramidite method using a carboxylic acid as a promoter

Masaki Tsukamoto1,2, Erkki J. Nurminen1, Toshihiro Iwase1,2, Masanori Kataoka3 and Yoshihiro Hayakawa1,2

1 Graduate School of Information Science, Chikusa, Nagoya 464-8601, Japan, 2 CREST, JST, Nagoya University, Chikusa, Nagoya 464-8601, Japan, 3 National Institutes of Natural Science, Research Center for Computational Science, 5-1 Higashiyama, Myodaiji, Okazaki 444-8787, Japan

This paper describes utility of a carboxylic acid, such as 2,4-dinitrobenzoic acid, as a promoter for internucleotide-linkage formation via the phosphoramidite method.


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