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Nucleic Acids Symposium Series 2004 48(1):265-266; doi:10.1093/nass/48.1.265
© 2004 by Oxford University Press
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Screening of modified DNA aptamers that recognize DNA secondary structure

Masayasu Kuwahara, Toshiyuki Kasamatsu, Masatoshi Hasegawa, Atsushi Shoji, Hiroaki Ozaki and Hiroaki Sawai

Department of Applied Chemistry, Gunma University, Kiryu, Gunma 376-8515, Japan

We attempted to utilize in vitro selection techniques to develop modified DNA aptamers that are specific for DNA secondary structure including a single-mismatch base pair. For the selection, two kinds of random modified DNA library were prepared by an enzymatic method using modified 2'-deoxynucleoside 5'-triphosphates and KOD Dash DNA polymerase: one library consists of modified DNA including amino functionality and another consists of modified DNA including both hydroxypropynyl and guanidium functionalities.


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