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Nucleic Acids Symposium Series 2004 48(1):39-40; doi:10.1093/nass/48.1.39
© 2004 by Oxford University Press
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Topological stabilization of PNA-DNA invasion complex

Toru Sugiyama1, Reiko Kuroda1 and Atsushi Kittaka2

1 Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902, Japan, 2 Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 199-0195, Japan

We propose the concept of a PNA-DNA (PD) padlock exploiting a topological link between PNA and DNA. We synthesized padlock-forming PNAs and demonstrated the validity of this concept by gel shift assay. We also suggest a design principle for padlock-forming PNA.


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