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Nucleic Acids Symposium Series 2004 48(1):59-60; doi:10.1093/nass/48.1.59
© 2004 by Oxford University Press
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Synthesis of oligonucleotide containing 4'-o-nitrobenzyloxythymidine and its reactivity

Mariko Aso, Mitsuhiro Fukuda, Kazuteru Usui and Hiroshi Suemune

Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan

We synthesized oligonucleotide (1) containing 4'-o-nitrobenzyloxythymidine (2), which was prepared by reaction of 4', 5'-unsaturated thymidine with m-CPBA followed by Lewis-acid catalyzed addition of o-nitrobenzylalcohol. The duplex stability of 1 with the complementary oligonucleotide was studied by Tm measurement. Photochemical reaction of 1 to generate C4'-oxidized abasic site containing oligonucleotide (3) was studied.


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