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Nucleic Acids Symposium Series 2004 48(1):67-68; doi:10.1093/nass/48.1.67
© 2004 by Oxford University Press
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Stable hairpins having a loop consisting of 3'-deoxy-4'-C-(2-hydroxyethyl)thymidines

Satoshi Shuto1, Yutaka Tamura2, Yuji Yamamoto1, Tetsuya Kodama1, Shuichi Hoshika1, Satoshi Ichikawa1, Yoshihito Ueno3, Eiko Ohtsuka2, Yasuo Komatsu2 and Akira Matsuda1

1 Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan, 2 National Institute of Advanced Industrial Science and Technology, Sapporo 062-8517, Japan, 3 Faculty of Engineering, Gifu University, Gifu 501-1193, Japan

A novel sugar-modified thymidine analogue, 3'-deoxy-4'-C-(2-hydroxyethyl)thymidine (X), was designed and synthesized to show that it can stabilize hairpin structures when it is present in the loop moiety, probably due to the flexibility of the one-carbon-elongated 4'-branched structure.


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